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SKU PP-ONC-PNC27-5MG
PNC-27 is a synthetic peptide combining the HDM-2 (MDM2)-binding region of human p53 with a membrane-penetrating peptide sequence derived from penetratin, studied for tumor-selective membrane targeting. Supplied for laboratory and educational research only.
Studied for binding to HDM-2 (MDM2) expressed on the surface of certain tumor cells, with preclinical reports describing rapid membrane pore formation and loss of membrane integrity, distinct from classical apoptosis. The precise mechanism remains under active investigation.
Experimental oncology research, including studies of HDM-2 receptor biology, p53 signaling, and cell-membrane targeting in breast, colon, pancreatic, ovarian, and leukemia research models. Evidence remains preclinical, with no approved therapeutic indication.
Summarized from published research literature for informational purposes. Not a recommendation for use, and not an indication that this product is approved or intended for human or veterinary use.
Store lyophilized powder at -20°C, protect from light, moisture, and heat
Refrigerate at 2-8°C for short-term use. For extended storage, aliquot and freeze at -80°C, avoid repeated freeze-thaw cycles
Included per batch
Independent HPLC testing
LC-MS, batch matched
Yes. Reputable batches ship with a lot-specific CoA covering HPLC purity, mass spectrometry identity confirmation, and peptide sequence verification.
This product is sold for laboratory and educational research use only. It is not intended for human or veterinary use, and is not a drug, food, or cosmetic under applicable law unless explicitly labeled as such. Statements on this page have not been evaluated by any regulatory authority.
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